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In 2014, two research groups independently reported that circulating TMAO levels were significantly higher in patients with chronic heart failure than those without HF (median fasting TMAO value of 5.0 vs

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doi: 10.3390/ijms22041988 [DOI] [PMC free article] [PubMed] [Google Scholar] 2

2) Vitamins D and B In a small study on 52 adults, supplementation with vitamins B and D decreased TMAO levels [58]

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A widely accepted international classification of peripheral artery disease (PAD) is Fontaines classification (Fontaine 1954)