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1999 Simone J

In neurodegenerative diseases, such as Alzheimer's disease, GABAergic dysfunction compounds the excitotoxic damage caused by excessive glutamate activity, exacerbating neuronal degeneration

Continuous positive airway pressure for adults with obstructive sleep apnea and cardiovascular disease: a meta-analysis of randomized trials

Stufano A, Isgr C, Palese LL, Caretta P, De Maria L, Lovreglio P, et al

In that study, C max was 2397.81 709.54 ng/mL, t max was 1.01 0.73 h and AUC 0 was 8287.27 2418.68 ng h/mL

Modulating EAAT2, AQP4, and purinergic signaling offers a unique opportunity for targeted intervention, selectively disrupting neurotoxic cascades while preserving the essential homeostatic functions of astrocytes