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Sometimes it's about removing protective mechanisms

Similar to most TRPs, TRPML is mainly up-regulated, but in some cases down-regulated, by phosphatidylinositol 3,5-bisphosphate [PI(3,5)P 2 ], found in lysosomes (Dayam et al., 2015

Regulatory status

It begins below the obesity-trial floor because appetite and gastrointestinal effects need time to adapt before escalation
