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In LNCaP cells, oxymetazoline demonstrated more potent ERK 1/2 activation than treatment with noradrenaline, behavior that is commonly observed with -arrestins biased agonists

Lih-Brody L, Powell SR, Collier KP, Reddy GM, Kahn E, Weissman GS, Katz S, Floyd RA, McKinley MJ, Fisher SE, and Mullin GE (1996)

PMCID: PMC5239707

Published research on Thymosin Beta-4 includes Phase II clinical trials in wound healing that showed significant improvement compared to placebo

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Polymorphisms in the CYP2D6 and CYP3A5 genes, for example, can alter the metabolism of metoprolol and amlodipine, respectively, and influence optimal dosing regimens [179,180]