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However, this is disputed due to the small number of mitochondria in eosinophils and the high energy required for release of mtDNA ( EETs can form networks to capture and kill bacteria, as part of their antibacterial mechanism, but can also cause tissue damage and amplify inflammation under pathogenic conditions (Yousefi et al., 2008

2010, 140 , w13080

The presence of two significant elements in the regulatory region of the MT-1 and MT-2 genes, namely, the TATA box (serving as the core promoter element) and multiple cis-acting response elements, including metal-responsive elements (MREs) and antioxidant-responsive elements (AREs), drives their expression [32]

PERK, Protein kinase RNA-like ER kinase

Nevertheless, PS translocation to the outer leaflet of the phospholipid bilayer, a hallmark of eryptosis, can frequently occur without caspase-3 recruitment, primarily in response to Ca 2+ overload [84]

doi: 10.1007/s13539-012-0059-5