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doi: 10.1038/sj.embor.7400559

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However, its often recommended to space the doses apart by a few hours to maximize efficacy

Nevertheless, challenges associated with BMP-2 include its short half-life, complex production equipment and preparation process, as well as supraphysiological doses, which may lead to side effects such as inflammation, pain, heterotopic ossification, or even osteolysis [403]

Or you might hit steady state at the higher dose two weeks later and suddenly experience debilitating nausea that would not have occurred with proper timing