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Talk With Your Doctor If you have a skin reaction to any type of vitamin B supplement, stop using it and ask your doctor how to proceed
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Several factors may hinder the absorption of natural food folate, e.g., partial release from the food matrix (incomplete liberation from cellular structures), destruction within the gastrointestinal tract, and incomplete hydrolysis of polyglutamates to monoglutamates (possibly mediated by partial inhibition of deconjugation enzymes by other dietary constituents such as organic acids)