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RESULTS Epitalon reduces the level of reactive oxygen species in aged oocyte A previous study showed that the accumulation of intracellular ROS is an important manifestation of post-ovulatory oocyte aging

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By blocking NNMT, it prevents the methylation and disposal of nicotinamide, raising intracellular NAD+ levels and activating SIRT1-mediated fat oxidation

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Seshadri S, Destefano AL, Au R, Massaro JM, Beiser AS, Kelly-hayes M, Kase CS, Dagostino RB, Decarli C, Atwood LD, Wolf PA (2007) Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham study