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[DOI] [PMC free article] [PubMed] [Google Scholar] 69.De Rosa S.C., Zaretsky M.D., Dubs J.G., Roederer M., Anderson M., Green A., Mitra D., Watanabe N., Nakamura H., Tjioe I., et al

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A major concern in using primary hepatocytes for drug safety analysis is their rapid dedifferentiation in static culture resulting in a loss of hepatic phenotype and functionality within hours of the isolation procedure (Yixin et al., Research into factors driving liver zonation have reported several mechanisms by which the different metabolic zones arise (Kietzmann, We would like to emphasize that a number of assumptions have been made in our mathematical model (see Supplementary Material)

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