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Together, these actions are thought to produce more pronounced weight loss and metabolic improvements than dual or single receptor agonists

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The decision to continue, adjust, or discontinue therapy should be based on objective body composition measurements (DEXA scans, circumference measurements), achievement of fat loss goals, tolerance and side effect profile, and physician assessment of metabolic markers

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The NHS notes that taking up to 2,000 micrograms daily is unlikely to cause harm in most people, though there is generally no benefit to such excessive amounts without confirmed deficiency