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Chronic hypoxia-induced -syn pathology and cognitive impairment in mice remain irreversible after reoxygenation We have found that chronic hypoxia promoted the abnormal pathology of -syn through an HIF-2-dependent pathway, which is an important link in inducing neuronal injury and cognitive impairment in mice

While its mechanisms are complex and wide-ranging, questions of delivery and dosing remain front of mind for both researchers and clinicians

Acknowledgments We thank Sascha Martens and Christian Zierhut for critical feedback on the manuscript

Most people will absorb it either way

The optimal dose of dried schisandra fruit for human administration is 26 g per day
