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2.2 Intervention in the PI3K/AKT and its associated signaling pathways The phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway is a well-established biological process involving the regulation of diverse signalings such as apoptosis, metabolism, cell proliferation and growth, protein synthesis, transcription, glucose uptake, and aerobic glycolysis in cancer cells ( 2.2.1 Inhibition of the PI3K/AKT signaling pathway Most listed active constituents address the functions to suppress the PI3K/AKT signaling pathway

Thermo Fisher Scientific), supplemented with dox (2 g/ml), and ROCK inhibitor (RI

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Although the surrounding acinar cells exhibited endoplasmic reticulum stress and karyopyknosis, the invading lymphocytes retained the morphological features of mitochondrial cristae ( Figure 7B )