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S -nitrosylation of proteins alters their activity directly

The iron-loaded transferrin is then recognized by the cell membrane receptor TfR1 and translocated into endosomes via the receptor-mediated endocytosis pathway, where ferric ions are released from the transferrin in acidic endosomes and then reduced to Fe 2+ by the enzyme prostate 3 metal reductase (STEAP 3) (71)

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doi: 10.1016/s0196-9781(99)00139-4

This not only may lead to treatment interruption but also may increase the risk of malnutrition and dehydration caused by reduced intake [64]

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