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These obstructions made of keratin, cellular debris, granulation tissue, and/or fibrosis can increase stress, contribute to progression of disease, result in lid tenderness, inflammation, recurrent eyelid infections (styes, hordeola, chalazia, cellulitis), and other symptoms of ocular irritation, and can exist simultaneously with traditional MGD

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2) the gut microbiota might be not only the pharmacological target, but also the main site of metabolism, resulting in a low oral bioavailability

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You should always tell the doctor if you are taking any other medicines, herbal preparation and supplements to avoid any interaction