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This review provides an overview of the GSH transporter and the status of GSH transporter-based brain targeting drug delivery systems with the intention of bringing the field to the attention of a medicinal chemist for his/her expertise in organic synthesis, ligand identification and optimization

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Moreover, a substantial body of literature data shows that the extractable activity of GR is the lowest of the classical ascorbate-glutathione pathway enzymes

Thus, amygdalin has been shown in vitro experiments to induce apoptosis due to upregulated expression of caspase-3 and Bax protein and downregulated expression of Bcl-2, an anti-apoptotic protein (217) ( Table 2 )

doi: 10.3389/fphar.2018.01162 Received 30 May 2018 Accepted 24 September 2018 Published 16 October 2018 Volume 9 - 2018 Edited by Andres Trostchansky, Universidad de la Repblica, Uruguay Reviewed by Suowen Xu, University of Rochester, United States

doi: 10.3389/fnut.2020.604283
