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In H2O2-induced human corneal epithelial cells, esculetin (20-100 M) activates the Nrf2 signaling pathway, inducing the expression of multiple antioxidant genes, including HO-1, quinone 1 (NQO1), glutamate cysteine ligase modifier subunit (GCLM), SOD1 and SOD2, thereby inhibiting ROS generation and accumulation (37)

Ellagic acid treatment (30 mg/kg bm, 14 days) could reduce oxidative stress by reducing the levels of MDA and NO and enhancing the activity of endogenous antioxidant enzymes such as CAT, SOD, GPx, thereby effectively alleviating the cardiotoxicity induced by arsenic (10 mg/kg bm, p

[23] What side effects should I watch for

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FRGs Through bioinformatics methods, the expression profile of a set of FRGs can be analyzed in patient tissues or peripheral blood cells to construct prognostic models