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doi:10.1007/s00405-018-5146-6 Karatas A, Acar Yuceant G, Yuce T, Haci C, Cebi IT, Salviz M

However, when the allostatic systems are overworked beyond a tipping point , the capacity to respond acutely and appropriately functions poorly and, if the immunologic memory is for an inflammatory or autoimmune response within the nervous system, the shorter-term stress effect could exacerbate into a chronic disease process [357], generating heterogeneous ASD behavioral phenotypes with heterogeneity deriving from interindividual systems differences

doi: 10.3109/10717544.2014.907372 231

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[DOI] [PMC free article] [PubMed] [Google Scholar] 169.Graziani G., Artuso S., De Luca A., Muzi A., Rotili D., Scimeca M., Atzori M.G., Ceci C., Mai A., Leonetti C., et al