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In practice, stacking multiplies uncertainty: more compounds more chances of impurity/contamination more pathways affected more interaction risk more variables harder to know what helped (or harmed) If you take only one clinical principle from this article: the more experimental the stack, the more conservative your risk posture should be
doi: 10.1039/C3MT00185G, PMID: [DOI] [PubMed] [Google Scholar] 118.Pegoraro S, Fiori S, Cramer J, Rudolph-Bhner S, Moroder L
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