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doi: 10.1002/biof.5520170120

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4-Hydroxynonenal 4-Hydroxynonenal (4HNE) is a lipoperoxidation-derived aldehyde that can damage proteins and DNA through the generation of covalent adducts and is implicated in the control of cell signaling 13,14

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[Abstract]2026 Feb 14;17(1):224

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Science 319 , 962965 (2008)

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Whilst aprocitentan is not metabolized to an active metabolite, it itself is the active metabolite M6 of the drug macitentan (Opsumit)

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