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For the FDA-approved dose of oral naltrexone, which is much higher than LDN, that is used to treat alcohol and opioid use disorder, it is considered safe to initiate opioids after discontinuing naltrexone for at least 72 hours

32, 33 found significantly increased 3-nitrotyrosine (3-NT), a marker of oxidative protein damage, while noting a trend of increased 8-oxo-deoxyguanosine (8-oxo-dG), a marker of oxidative DNA damage

Surgical resection remains challenging due to the aggressive nature of GBM and the difficulty in defining their margins [3]