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GHK exists naturally in saliva and urine as well, released from extracellular matrix proteins including SPARC and the collagen 2(I) chain during tissue injury, functioning as a matrikine damage signal that activates repair mechanisms

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One of the keys to that communication is healthy synapses, which are the connection points between brain cells

Bone, Connective Tissue, and Vascular Effects GHK-Cu promotes bone healing, enhances osteoblastic cell attachment, and increases collagen synthesis in bone cells

Experimental work has also examined how follistatin modulates ligand availability across cell culture and animal research systems