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GDH1-derived AKG directly engages and activates the IKK-NF-B signaling axis, thereby upregulating the expression of the glucose transporter 1 (GLUT1) to promote compensatory glucose uptake and tumor cell survival under low glucose conditions [133]

Alzheimers Res Ther 13:154 [DOI] [PMC free article] [PubMed] [Google Scholar] 58.Brody M, Agronin M, Herskowitz BJ, Bookheimer SY, Small GW, Hitchinson B, Ramdas K, Wishard T, McInerney KF, Vellas B et al (2023) Results and insights from a phase I clinical trial of Lomecel-B for Alzheimers disease
In dogs, GNB1 mutations have been detected in cutaneous and subcutaneous MCTs, with a trend towards a positive prognosis [41]
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PubMed Central , FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology , vol
