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Description
This is because phosphorylation can cause conformational changes in the enzyme that decrease its ability to catalyze the reduction of 5,10-MTHF to 5-MTHF [96,98]

Hyperpolarized [1, 13 C]pyruvate in lysed human erythrocytes: effects of co-substrate supply on reaction time courses
doi: 10.1080/07315724.2014.926153

Profile of altered brain iron acquisition in restless legs syndrome

2002, 282 (2), E247-58

The genius was in identifying it, stabilizing it, and then beginning the formidable task of understanding its vast range of effects
