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The authors did not find any difference in disc degeneration using MRI at a mean follow up of 18.6 years

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Furthermore, recent clinical trials, despite great variability in efficacy outcomes, have consistently confirmed the favorable safety profile of NAC across a wide range of therapeutic areas

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PRIMUS: Comprehensive Proteomics of Mouse Intervertebral Discs that Inform Novel Biology and Relevance to Human Disease Modelling