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For example, even in the recent study, four people returned to their original dosing schedule after they began regaining weight

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Weight loss and thyroid hormone requirements : Substantial weight loss achieved through GLP-1 therapy may alter thyroid hormone requirements

if anything, nausea-driven appetite suppression enhances caloric deficit

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FDA has increasingly focused on escalating its enforcement activity against compounded GLP-1 drugs following US President Donald Trumps September 9, 2025, memorandum on prescription drug advertisements, which called on the FDA commissioner and the secretary of the US Department of Health and Human Services (HHS) to take actions to enforce prescription drug advertising laws and regulations