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EGF relays signals to COP1 and facilitates FOXO4 degradation to promote tumorigenesis

& Hao, W
All authors contributed to the experimental designs, analysis, and interpretation of the experimental work in this publication

Increased stress can directly damage the disc, disrupt intradiscal pressure balance, and cause structural alterations
Treating true deficiency can improve deficiency-related symptoms (including anemia-related fatigue and neurologic issues) (see the NIH ODS Vitamin B12 fact sheet )

Dec 15 2022;9(1):85-93