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At therapeutic doses, healthy livers detoxify NAPQI by phase II conjugation with glutathione (GSH) to form inert mercapturate and cysteine metabolites

M.KimM.-S.UmanahG.et al (2014)
LapennaDde GioiaSCiofaniGMezzettiAUcchinoSCalafioreAMet alGlutathione-related antioxidant defenses in human atherosclerotic plaques

If the patient is not adequately blocked, and has pain during the reduction maneuver, they may be able to overpower the treating physician and prevent reduction