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"The measurement of glutathione in human epidermis using glutathione reductase"

Smith JE, et al

[DOI] [PubMed] [Google Scholar] 72.Handa O., Naito Y., Yoshikawa T

Glutathione is a tripeptide its made from three amino acids (glutamine, cysteine, and glycine) and the liver produces it continuously

This can be achieved by contact-dependent signaling [juxtracrine signaling], by the release of exosomes in close proximity to the source [paracrine signaling], or by endocrine signaling whereby exosomes are then transported systemically via the bloodstream to act distally

Zone 2 bridges the periportal and pericentral zones, experiencing a gradient in oxygenation and metabolic activity throughout the liver lobule 120