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The formation of leukotriene A4 (LTA4) from arachidonic acid is catalyzed by 5-Lipoxygenase, and during the reaction leukotrienes acts as a crucial amboceptor

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Thus, while metrics of cerebral autoregulation appear to be impaired immediately following resistance exercise, increased autoregulatory gain (change in MCAv relative to change in blood pressure) should not be misinterpreted as damaging but instead as oppositional to weightlifters blackout

[DOI] [PubMed] [Google Scholar] Dinges DF, Douglas SD, Zaugg L, Campbell DE, McMann JM, Whitehouse WG, Orne EC, Kapoor SC, Icaza E, Orne MT