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are currently becoming common diseases

Meister A, Anderson ME

There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH

The decrease in GSH disrupted the REDOX balance, preventing the consumption of intracellular ROS and lipid peroxides, and contributing to oxidative stress in cells, manifesting as a decrease in antioxidant proteins and the appearance of DNA damage

Dissolution and bioavailability improvement of bioactive apigenin using solid dispersions prepared by different techniques

EtOH/POA also promotes calcium overload and nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase activation
