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Nevertheless, we argue that a cytodegeneration of the myelinating unit may be the most proximal event, which could be potentially driven by a protein misfolding mechanism like most other neurodegenerative disorders

It fundamentally alters the neuroimmune landscape

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Clinical Trial Safety Data Phase 1 trials (healthy volunteers): The first human safety studies in healthy volunteers showed excellent tolerability

In addition, targeted evidence-based supplements may support the maintenance of balanced testosterone and other hormone levels

These findings establish NNMT inhibition as a viable pharmacological approach to combat sarcopenia and age-related muscle decline