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In this classic signaling pathway, ligand-activated ER dissociates from its chaperone heat-shock protein and binds as a dimer either directly to an estrogen response element (ERE) in target gene promoters or indirectly to activator protein 1 or specificity protein 1 response elements through protein tethering to DNA (13)

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Cell Stem Cell 29 , 973989.e910 (2022)

Adipocyte energy expenditure published animal models have explored NNMT inhibition with 5-Amino-1MQ in diet-induced-obesity rodents, examining adipose-tissue mass, energy expenditure, and metabolic markers

[DOI] [PubMed] [Google Scholar] 114

Protein disulfide isomerase is a multifunctional regulator of estrogenic status in target cells