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Pizzagalli et al

Gen Physiol Biophys 37:2331

Five participants completed the study with mostly good adherence to prescribed menus, while one participant dropped out due to inability to prepare the diet and another withdrew from the study for unrelated reasons

Consistently, Ch25h / mice had reduced TNF and IL-6 production, accompanied by impaired NK cell and neutrophil infiltration into the hippocampus

The researchers concluded that because ROS restriction saturated at lower concentrations (100 nM) while cell cycle modulation continued at higher concentrations (up to 500 nM), Pinealon likely interacts directly with the cell genome or gene expression factors in addition to its antioxidant activity

Eur J Immunol (2016) 46:92103