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Phase II and III studies that looked at combination regimens found that they helped people lose weight more effectively than single-therapy

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The application of angiogenic molecules, such as VEGF-A, known as vascular permeability factor, may enhance the permeability of capillaries

Ocular safety has also emerged as a key consideration in GLP-1 RA therapy, encompassing worsening of diabetic retinopathy (DR), particularly in semaglutide users with pre-existing DR at baseline, as well as ischemic optic neuropathy (ION) [75,98,99]

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