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Abstract The therapeutical benefits of methotrexate (MTX) antifolate agents are non-negligible

For example, correcting magnesium deficiency can reduce cardiovascular morbidity risk by up to 22% in high-risk populations (NIH 2023)

The formulations efficacy is based on dextromethorphans effect on neurotransmission, which can mitigate excitotoxic effects, coupled with quinidines ability to enhance dextromethorphans cerebral presence by inhibiting efflux transporter activity (49)

In searching for potential new targets for the development of effective drugs against MASLD, we found that glutathione S-transferase alpha 1 (GSTA1) may be related to the accumulation of lipid droplets (LD)

256,257 Besides, MT3s important contribution to osteoblast differentiation is by counteracting oxidative stress

Tryptophan-Derived Neurotransmitters Tryptophan serves as the precursor for the synthesis of serotonin (5-hydroxytryptamine, 5-HT, see also Biochemistry of Nerve Transmission) and melatonin ( N -acetyl-5-methoxytryptamine)