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Safety: Preclinical studies showed no acute toxicity across organ systems and no evidence of mutagenicity or teratogenicity

2022 Jul 12;27(14):4459

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doi: 10.1001/jama.294.16.2122

Frey II, a pioneer in intranasal central nervous system (CNS) delivery and adjunct professor at the University of Minnesota, explained it perfectly: We proved you could noninvasively deliver stem cells to the brain from the nose

Taken as a prisoner of war at Old Church, Virginia, on June 10, 1864, he was paroled on April 9, 1865, and discharged on June 8, 1865