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A significant fraction of the heme moeity may be converted to metabolites other than bilirubin, such as mesobilifuscins, that are excreted in the bile/feces and urine ( Heterozygote females are often considered only as carriers, leading to under-diagnosis of G6PD deficiency as the underlying cause of severe hyperbilirubinemia

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Moreover, the gut is innervated by structures dependent on the same type of neurons and neurotransmitters found in the CNS, which are actively enlisted in cross talk with the brain by neurons, the immune system, and hormones [53, 56, 58]

In M2 macrophages, Arg1 expression is promoted via the STAT6 pathway (150) and can be synergistically induced by IL-10 and LPS (151)

Comp Immunol Microbiol Infect Dis 2004;27:1-5

[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Koob GF, Volkow ND