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showed that hydroxytyrosol (HT) can present an endothelial protective effect by decreasing the formation of superoxide anion in the mitochondria of PMA-activated endothelial cells, reducing membrane lipid oxidation by promoting SOD activity

PMID: 28263971, PMCID: PMC5501754, PII: onc201723, DOI: 10.1038/onc.2017.23, ISSN: 1476-5594

Lead induced oxidative damage and its response to combined administration of -lipoic acid and succimers in rats

Using both an Ang II-induced in vitro cardiomyocyte hypertrophy model and a TAC-induced in vivo cardiac hypertrophy model, they observed that TSA markedly inhibited cardiomyocyte hypertrophy and downregulated hypertrophy markers such as ANP, BNP and -MHC

The sigma class is encoded by gene located on the long arm of chromosome 4 (4q21-22) [15, 18]

This study first highlights the non-cell-autonomous nature of ferroptosis