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[ 7 ] Questions arose whether DSIP truly exists as a naturally occurring peptide in humans or whether the observed activity represented related peptide fragments

10.1038/sj.bjp.0701568 46 CrabbeJ

38 , 39 The US Institute of Medicine has recommended that adults older than 51 years consume most of their vitamin B 12 from fortified foods or supplements, bearing in mind that older adults are at higher risk of B 12 deficiency due to the physiological reduction in intrinsic factor secretion necessary for absorbing this vitamin, as well as due to the use of drugs that can reduce the bioavailability of cobalamin

International journal of molecular sciences, 24(23), 16588

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B-complex vitamins are water-soluble, so it is important to regularly consume them through food or supplements to maintain adequate levels