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In addition to the regulatory role of hepcidin, the expression of iron transporters such as transferrin receptor 1 (Tfr1) and transferrin is crucial for understanding the dynamics of cardiac iron overload ( The therapy targeting the hepcidin-transferrin axis has demonstrated initial potential, capable of effectively alleviating iron overload and ineffective erythropoiesis

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This ring is not directly involved in the catalytic function of GSTs but forms hydrogen bonding interactions with the backbone amine group of the cysteine-residue of GSH and plays an important role in maintaining the protein in a catalytically active structure [28,29]

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Dall'Era, M

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