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Interestingly, when ghrelin is administered alone to cells coexpressing D1R and GHSR1a, no increase in cAMP accumulation is observed, while typical levels of Ca 2+ accumulation associated with GHSR1a activation occur (Jiang et al., 2006)

These findings highlight the fact that not all PAMs of a given receptor behave similarly in vivo , which must be taken into account when designing studies evaluating their therapeutic potential

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