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Specifically, the rate of DNA damage repair following irradiation is significantly reduced when the activation of IGF1R was absent, both in immortalized human keratinocytes and in primary human keratinocytes

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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable