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Interestingly, as predicted by the Igfbp4-ko and the pappa-ko animal models described previously, a human PAPP-A2 gene defect with growth phenotype was recently reported as detailed below (43)

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AOD 9604 is a modified peptide initially developed as an offshoot in obesity research

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While the clinical trials demonstrated excellent safety in generally healthy obese adults, individual medical histories may reveal concerns not apparent in trial populations