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doi: 10.1002/hep.27265

AgarwalABaskaranSParekhNChoCLHenkelRVijSet al

Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose

Tetrahedron Letters, 26(16), pp.2013-2016

In H2O2-induced human corneal epithelial cells, esculetin (20-100 M) activates the Nrf2 signaling pathway, inducing the expression of multiple antioxidant genes, including HO-1, quinone 1 (NQO1), glutamate cysteine ligase modifier subunit (GCLM), SOD1 and SOD2, thereby inhibiting ROS generation and accumulation (37)

and B.A.K.), R34 HL128798-01 (B.A.K) and institutional funds from the Bloodworks Research Institute
