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DISCUSSION The goal of this study was to develop an AnglV-derived molecule that retained the pro-cognitive/anti-dementia activity of AnglV and Nle'-AnglV but possessed improved pharmacokinetic properties, thus allowing it to penetrate the BBB in sufficient quantities to reach therapeutic levels in the brain

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SUPPLEMENTARY FIGURE S2 Representative merged CD11b/DAPI images of SCI (12 weeks after injury) (A) and DCM (24-week-old ttw/ttw mice) (B) models in the brain

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Field Cycle frequency Reported range 2 to 3 cycles per year Note Spaced out 2 to 3 months apart in the published reports