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Description
A notable example is the fusion protein abatacept (Orencia) for arthritis, where C220S/C226S/C229S/P238S mutations in the linked Fc moiety led to significant decrease of cytotoxicity associated with CDC and ADCC 37
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TGF-beta Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma
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Science 190 , 397399 (1975)
