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Considering that ASD is stable to P450 enzymes, characterized by high solubility, low permeability and classified as BCS 3 compound, the low bioavailability could be attributed to the poor gastrointestinal absorption rather than to potent first pass metabolism

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[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Suzuki T

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Similarly, there is risk in most studies of underreporting PDAC events due to ascertainment bias, because active surveillance is not typically performed in controlled trials or performed in routine clinical practice

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