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Toxic bile salts retention in the liver is accompanied by intracellular metabolic disorders, inflammation and reduced detoxification capacity [176], which may enhance the generation of oxidative stress and the accumulation of ROS and RNS in hepatocytes [177], leading to generalized systemic damage to major organs, starting from the liver and reaching the brain, heart, intestine, and kidney [178,179,180]

Its core vulnerability is chemical: the active sulfhydryl group (SH) on cysteine oxidises rapidly on exposure to gastric acid, digestive enzymes, heat, and light

Acute effects of glaucoma medications on rat intraocular pressure

The heat shock response: life on the verge of death

Chin J Appl Physiol

J Chin Med Assoc