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J Oral Maxillofac Surg 59(9):10121017

Gene sequencing indicated an -thalassemia minor and that probably masked the megaloblastic features of vitamin B 12 deficiency

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The occurrence of the sub-clinical deficit has been highlighted by their measurement, but its effects have not yet been fully understood [23]

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While the earlier clinical trials also had good response rates in consideration of patients who achieved transfusion independence, the patient cohorts treated in those studies had predominantly less severe -thalassemia genotypes with 44% ( n = 8 of 18 patients) and 25% ( n = 1 of 4 patients) 3 as compared to the current study in which all 18 patients treated had severe genotypes