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Of note, metformin accumulates in tissues at concentrations several times higher than those in the blood and the positive charge on metformin has been indicated to promote its accumulation in the mitochondrial matrix 20 mmol/l)

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Compared with cisplatin alone, this combination significantly enhances the inhibition of NSCLC xenograft tumour growth in vivo [246]

doi: 10.1016/j.heliyon.2023.e16773